Phospho-Amyloid Precursor Protein (Thr668) Polyclonal Antibody, AbBy Fluor™ 680 Conjugated

Product Specifications

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Synonyms

Amyloid Precursor Protein phospho Thr743; Amyloid Precursor Protein phospho Thr743; p-Amyloid Precursor Protein phospho Thr743; APP Thr743

Gene ID

351

Swiss Prot

P05067

Modification Site

Thr743

Cellular Locus

Cytoplasm, Nucleus, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-Amyloid Precursor Protein (Thr668)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 680

Source

KLH conjugated synthetic phosphopeptide derived from human APP around the phosphorylation site of Thr743

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

679nm/702nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

351

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TR504616 1 Kit

Slc16a14 Mouse shRNA Plasmid (Locus ID 71781)

Ask

View Details

6431-08 0.5 mg

Donkey F (ab') 2 Anti-Rat IgG (H+L), Mouse SP ads-BIOT

Ask

View Details

MP200256 200 Reactions

Atf5 Mouse qPCR Primer Pair (NM_030693)

Ask

View Details

MBS8434549 Inquire

Rat Lipocalin-2 Recombinant Protein DDDDK Tag

Ask

View Details

E48GA028 100 µL

Goat anti-Ki67 Polyclonal Antibody

Ask

View Details

SI202724A 1 Each

Rat Chrm2 Pre-designed siRNA Set A

Ask

View Details