Phospho-arfaptin 2 (Ser260) Polyclonal Antibody

Product Specifications

Background

ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.

Synonyms

ADP ribosylation factor interacting protein 2; Arfaptin 2; ARFIP2; Partner of RAC1; POR1; ARFP2_HUMAN.

Gene ID

23647

Modification Site

Ser260

Cellular Locus

Cytoplasm

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-arfaptin 2 (Ser260)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human arfaptin 2 around the phosphorylation site of Ser260

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

23647

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Sheep, Rabbit

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