JNK3/MAPK10 Polyclonal Antibody

MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs) . Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4) . Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

CJun N terminal kinase 3; MAP kinase p49 3F12; Stress activated protein kinase JNK3; c Jun kinase 3; JNK3; JNK3A; MAP kinase; mitogen activated protein kinase 10; p493F12; p54bSAPK; PRKM10; protein kinase mitogen activated 10 ; stress activated protein kinase beta.