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ROM-K/Kcnj1 Polyclonal Antibody, Cy3 Conjugated

Product Specifications

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Synonyms

ROM K; ROM-K; inwardly rectying subfamily J member 1; ATP regulated potassium channel ROM K; ATP sensitive inward rectier potassium channel 1; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectier potassium channel 1; Inward rectier K+ channel Kir1.1; inwardly rectying K+ channel; IRK1_HUMAN; KCNJ 1; KCNJ; Kcnj1; Kir 1.1; Kir1.1; Potassium channel; Potassium channel inwardly rectying subfamily J member 1; potassium inwardly-rectying channel J1; ROMK 1; ROMK 2; ROMK; ROMK1; ROMK2.

Gene ID

3758

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Rat

Immunogen

301-391/391

Target

ROM-K/Kcnj1

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy3

Source

KLH conjugated synthetic peptide derived from human ROM-K/KCNJ1

Applications

FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

512,550nm/570,615nm

Concentration

1µg/µl

Dilution

FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

3758

Predicted Cross Reactivity

Human, Mouse, Dog, Cow, Pig, Horse, Rabbit

Curated Selection

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