TRPV4 agonist-1 (free base)

TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

Product Specifications

CAS Number

[2314467-59-7]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TRPV4_agonist-1.html

Purity

99.69

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C(F)C=CC=C51

Molecular Formula

C25H22F2N4O2

Molecular Weight

448.46

References & Citations

[1]Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4 (3 H) -ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.