KAT4/TAF1 Polyclonal Antibody

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.

TBP Associated Factor 1; BA2R; CCG 1; CCG1; CCGS; Cell cycle G1 phase defect; Cell cycle gene 1 protein; Complementation of cell cycle block G1 to S; DYT3 protein; NSCL 2; NSCL2; OF; p250; TAF 1; TAF 2A; TAFII250; TAF1; TAF1 RNA polymerase II TATA box binding protein TBP associated factor 250kDa; TAF1 RNA polymerase II TATA box binding protein TBP associated factor; TAF1 RNA polymerase II TATA box binding protein associated factor 250kDa; TAF1_HUMAN; TAF2A; TAFII 250; TAFII-250; TAFII250; TAF II P250; TATA box binding protein TBP associated factor RNA polymerase II A; TATA box binding protein TBP associated factor RNA polymerase II A 250kD; TBP associated factor 250 kDa; TBP-associated factor 250 kDa; Transcription factor TFIID p250 polypeptide; Transcription initiation factor TFIID 250 kDa subunit; Transcription initiation factor TFIID subunit 1.