Phospho-IRS1 (Ser307) Polyclonal Antibody, Cy5 Conjugated

Product Specifications

Background

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) .

Synonyms

HIRS-1; Insulin receptor substrate 1; IRS-1; IRS1

Gene ID

3667

Swiss Prot

P35568

Modification Site

Ser307

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-IRS1 (Ser307)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy5

Source

KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser307 [TE (p-S) IT]

Applications

FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

625,650nm/670nm

Concentration

1µg/µl

Dilution

FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This phosphorylation site is homologous to Ser302 in Mouse and Rat.

Gene ID URL

3667

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit

Curated Selection

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