SPECA Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
A-Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.
Synonyms
Fodrin alpha chain; ALPHAII-SPECTRIN; Alpha II Spectrin; FLJ44613; Fodrin, alpha; NEAS; Non erythrocytic spectrin alpha; SPECA; Spectrin alpha chain; Spectrin alpha chain brain; Spectrin alpha non erythrocytic 1; Spectrin non erythroid alpha chain; Spectrin, alpha, non-erythrocytic 1 alpha-fodrin; Spectrin, nonerythroid, alpha subunit; Spna2; SPTA 2; SPTA2; SPTAN 1; SPTAN1; SPTA1_HUMAN.
Gene ID
5795
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Immunogen
551-650/2472
Target
SPECA
Clonality
Polyclonal
Isotype
IgG
Conjugation
FITC
Source
KLH conjugated synthetic peptide derived from human SPECA
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
5795
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
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