Pentabromophenol

Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) [1][2].

Product Specifications

CAS Number

[608-71-9]

Product Name Alternative

PBP

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335, H400

Target

Apoptosis; TGF-beta/Smad

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pentabromophenol.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(=C(C(=C(C(=C1Br)Br)O)Br)Br)Br

Molecular Formula

C6HBr5O

Molecular Weight

488.59

Precautions

H301+H311+H331, H315, H319, H335, H400

References & Citations

[1]Chen CL, et al. Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Sci Rep. 2017;7:43206. Published 2017 Feb 23.|[2]Barańska A, et al. Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells. Molecules. 2022 Aug 9;27 (16) :5056.