JNK1+JNK2+JNK3 Polyclonal Antibody, APC-Cy5.5 Conjugated

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.

JNK3; Serk2; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK (beta) ; C238H4Rik; JNK; JNK1; Prkm8; SAPK1; AI849689; JNK2; Prkm9; AI85183; p54aSAPK; Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; MAP kinase p49 3F12; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; Mapk1; Prkm1