ACCN2 Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca (2+), Li (+) and K (+) . Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca (2+) entry into neurons upon acidosis. This Ca (2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca (2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Synonyms
Acid-sensing ion channel 1; ASICs1; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; AI843610; Amiloride sensitive cation channel 2 neuronal; ASIC; ASIC1; ASIC1A; B530003N02Rik; BNAC2; Brain sodium channel 2; Cation channel amiloride sensitive neuronal 2; hBNaC2.
Gene ID
41
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
ACCN2
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human ASIC1
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
41
Predicted Cross Reactivity
Cow, Horse, Chicken
Curated Selection
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