ACCN2 Polyclonal Antibody, AbBy Fluor™ 488 Conjugated
Product Specifications
Background
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca (2+), Li (+) and K (+) . Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca (2+) entry into neurons upon acidosis. This Ca (2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca (2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Synonyms
Acid-sensing ion channel 1; ASICs1; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; AI843610; Amiloride sensitive cation channel 2 neuronal; ASIC; ASIC1; ASIC1A; B530003N02Rik; BNAC2; Brain sodium channel 2; Cation channel amiloride sensitive neuronal 2; hBNaC2.
Gene ID
41
Cellular Locus
Extracellular
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
ACCN2
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 488
Source
KLH conjugated synthetic peptide derived from human ASIC1
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
499nm/519nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
41
Predicted Cross Reactivity
Cow, Horse, Chicken
Curated Selection
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