ACCN2 Polyclonal Antibody, APC-Cy7 Conjugated

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca (2+), Li (+) and K (+) . Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca (2+) entry into neurons upon acidosis. This Ca (2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca (2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Acid-sensing ion channel 1; ASICs1; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; AI843610; Amiloride sensitive cation channel 2 neuronal; ASIC; ASIC1; ASIC1A; B530003N02Rik; BNAC2; Brain sodium channel 2; Cation channel amiloride sensitive neuronal 2; hBNaC2.