ICOS Polyclonal Antibody, HRP Conjugated

Product Specifications

Background

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity) .

Synonyms

AILIM; CD278; CVID1; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; ICOS

Gene ID

29851

Swiss Prot

Q9Y6W8

Cellular Locus

Secreted, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

51-150/199

Target

ICOS

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Source

KLH conjugated synthetic peptide derived from human ICOS

Applications

WB, ELISA, IHC-F

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-F (1:100-500)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region.