Granzyme B + D + E + N + G + F + H Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
Protease required for lymphocyte cytotoxic granules to lyse target cells [RGD]. Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.
Synonyms
Granzyme D; Granzyme B; Granzyme E; Granzyme N; Granzyme G; Granzyme F; Granzyme H; Cathepsin G-like 2; CCP-X; CCP3; CCP4; CCP5; CGL-2; CSP-C; Ctla-5; Ctla-6; , Ctla-7; CTLA1; CTSGL2; Grz d; Grz e; Grz f; Grz g; GZMD; Gzme; Gzmf; Gzmg; GZMH; MCSP-2; MCSP-3; MGC117682; Rnkp7; mast cell proteinase-3-like; Cytotoxic T-lymphocyte proteinase; Granzyme H precursor; Cytotoxic serine protease-C; CSP-C.
Gene ID
2999
Cellular Locus
Cytoplasm, Nucleus, Secreted, Cell membrane
Host
Rabbit
Immunogen
151-252/252
Target
Granzyme B + D + E + N + G + F + H
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human Granzyme D/B/E/N/G/F/H
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2999
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse
Curated Selection
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