Histone H3 (tri methyl K9) Polyclonal Antibody, Cy5.5 Conjugated
Product Specifications
Background
Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
Synonyms
Histone H3 (Tri Methyl Lys9) ; H3K36me3; Tri methyl Histone H3 (Lys9) ; Tri methyl Histone H3 (K9) ; H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene; H31_TETTH; Histone H3; H3S; Histone H3-I/H3-II; Major histone H3; H3F; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l.
Gene ID
8350
Swiss Prot
P68431
Host
Rabbit
Cross Reactivity
Human
Target
Histone H3 (tri methyl K9)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy5.5
Source
KLH conjugated synthesised methylpeptide derived from human Histone H3 around the methylation site of tri methyl K
Applications
IF
Purification
Purified by Protein A.
Excitation Emission
675nm/694nm
Concentration
1mg/ml
Dilution
IF (IF=1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
8350
Predicted Cross Reactivity
Mouse, Rat, Cow
Curated Selection
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