Phospho-LRP5 (Thr1492) Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Gene ID
4041
Swiss Prot
O75197
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-LRP5 (Thr1492)
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated Synthesised phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492
Applications
IF
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1mg/ml
Dilution
IF ()
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-25114R-RBITC
Gene ID URL
4041
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig
Curated Selection
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