AKT-IN-3
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells[1].
Product Specifications
CAS Number
2374740-21-1
UNSPSC
12352005
Target
Akt; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt-in-3.html
Purity
98.12
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O
Molecular Formula
C23H23Cl2F2N5O3
Molecular Weight
526.36
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1; Akt2; Akt3
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![FOXO1 Mouse Monoclonal Antibody [Clone ID: OTI2C6]](https://cdn.genprice.uk/products/937/68dd18bb061270361e90893f/imageurl/cf810711.webp)
PTEN (Tumor Suppressor Oncoprotein) (PTEN/2110), 1mg/mL
Melanoma Marker (KBA.62), CF405S conjugate, 0.1mg/mL
