EF-5
EF-5 (EF5; 2-Nitroimidazole) is a hypoxia labeling agent used to identify hypoxia in cells.
Product Specifications
CAS Number
152721-37-4
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EF-5.html
Purity
98.29
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCC(F)(F)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O
Molecular Formula
C8H7F5N4O3
Molecular Weight
302.16
References & Citations
[1]Wang J, et al. The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia. Clin Cancer Res. 2012 Mar 15;18 (6) :1684-95.|[2]Evans SM, et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2- (2-nitro-1H-imidazol-1-yl) -N- (2,2,3,3,3-pentafluoropropyl) acetamide]. Br J Cancer. 1995 Oct;72 (4) :875-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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