Naphazoline (hydrochloride)

Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2].

Product Specifications

CAS Number

[550-99-2]

Product Name Alternative

Naphthazoline (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/naphazoline-hydrochloride.html

Purity

99.38

Solubility

DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

C1(CC2=NCCN2)=CC=CC3=CC=CC=C13.Cl

Molecular Formula

C14H15ClN2

Molecular Weight

246.74

Precautions

H315, H319, H320

References & Citations

[1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13 (4) :3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203 (1) :125-31.