GSK-3β inhibitor 10
GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC50 value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease[1].
Product Specifications
CAS Number
[1198098-03-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-10.html
Purity
98.04
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC(C=C1/C=C2C(N=C(S/2)N)=O)=C(C=C1)OC
Molecular Formula
C12H12N2O3S
Molecular Weight
264.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Arfeen M, et al. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors. Eur J Med Chem. 2016 Oct 4;121:727-736.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Available Sizes
Curated Selection
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