Suzetrigine phenol

Suzetrigine phenol is the phenolate form of the sodium channel modulator Suzetrigine (HY-148800) . Suzetrigine (VX-548) is an orally active and highly selective inhibitor of NaV1.8[1][2].

Product Specifications

CAS Number

[2649467-91-2]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/suzetrigine-phenol.html

Purity

99.39

Solubility

DMSO : 87.5 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C(N)=O)=NC=C1)[C@H]2[C@H](C3=C(O)C(F)=C(F)C=C3)[C@H](C)[C@](C)(C(F)(F)F)O2

Molecular Formula

C20H18F5N3O4

Molecular Weight

459.37

References & Citations

[1]Scarnati MS, et al. Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. Alcohol. 2019 Feb;74:83-93.|[2]Preparation of substituted tetrahydrofuran amides as modulators of sodium channels. World Intellectual Property Organization, WO2021113627 A1 2021-06-10.