Phospho-GEF H1 (Ser886) Polyclonal Antibody, APC-Cy5.5 Conjugated
Product Specifications
Background
GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho) . This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
Synonyms
GEF H1phospho S886; Arhgef2Ser886; Lbcl1; Lfc; mKIAA0651; AA408978; ARHG2; ARHGEF 2; ARHGEF-2; ARHGEF2; GEF; GEF H1; GEF-H1; GEFH1; LFP40; MGC95068; P40; Prolerating cell nucleolar antigen p40; Protein GEF-H1; rho/rac guanine nucleotide exchange factor GEF 2; rho/rac guanine nucleotide exchange factor 2; rho/rac guanine nucleotide exchange factor.
Gene ID
9181
Modification Site
Ser886
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Phospho-GEF H1 (Ser886)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy5.5
Source
KLH conjugated synthetic phosphopeptide derived from human Arhgef2 around the phosphorylation site of Ser886
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
9181
Predicted Cross Reactivity
Rat, Dog, Cow, Pig, Horse, Rabbit
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