Glypican 1 Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity) . May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparin sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Synonyms
FLJ38078; glypican; glypican1; GPC 1; Glypican-1; GPC1; Glypican proteoglycan 1; Gpc1; GPC1_HUMAN; Secreted glypican-1.
Gene ID
14733
Swiss Prot
Q9QZF2
Cellular Locus
Cytoplasm, Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
251-350/557
Target
Glypican 1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from mouse Glypican 1
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
14733
Predicted Cross Reactivity
Mouse, Dog, Cow, Sheep, Horse
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