Glypican 1 Polyclonal Antibody, AbBy Fluor™ 594 Conjugated

Product Specifications

Background

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity) . May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparin sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Synonyms

FLJ38078; glypican; glypican1; GPC 1; Glypican-1; GPC1; Glypican proteoglycan 1; Gpc1; GPC1_HUMAN; Secreted glypican-1.

Gene ID

14733

Swiss Prot

Q9QZF2

Cellular Locus

Cytoplasm, Secreted, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human, Rat

Immunogen

251-350/557

Target

Glypican 1

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 594

Source

KLH conjugated synthetic peptide derived from mouse Glypican 1

Applications

IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

590nm/617nm

Concentration

1µg/µl

Dilution

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

14733

Predicted Cross Reactivity

Mouse, Dog, Cow, Sheep, Horse

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