Polycystin 1 Polyclonal Antibody, APC-Cy5.5 Conjugated
Product Specifications
Background
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity) . May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
Synonyms
PBP; Pc-1; TRPP1; Polycystin-1; Autosomal dominant polycystic kidney disease 1 protein; PKD1
Gene ID
5310
Swiss Prot
P98161
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
131-230/4303
Target
Polycystin 1
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy5.5
Source
KLH conjugated synthetic peptide derived from human Polycystin 1
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
5310
Predicted Cross Reactivity
Mouse
Curated Selection
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