[Des-His1, Glu9]-Glucagon amide (TFA)

[Des-His1, Glu9]-Glucagon amide TFA is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. [Des-His1, Glu9]-Glucagon amide TFA is potentially useful in the study of the pathogenesis of diabetes[1].

Product Specifications

UNSPSC

12352209

Target

GCGR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/des-his1-glu9-glucagon-amide-tfa.html

Purity

98.36

Solubility

H2O : 6.67 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.OC(C=C1)=CC=C1C[C@H](NC([C@H](CCCCN)NC([C@H](CO)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@H](C(N)=O)[C@H](O)C)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O