SLX4/BTBD12 Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4 (XPF) -ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2 (TRF2) -TERF2IP (RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]
Synonyms
BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX 4; slx4; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) ; SLX4_HUMAN; Structure-specific endonuclease subunit slx4.
Gene ID
84464
Swiss Prot
Q8IY92
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
171-270/1834
Target
SLX4
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthetic peptide derived from human SLX4/BTBD12
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
84464
Predicted Cross Reactivity
Human
Curated Selection
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