SG3-179
SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S) [1][2].
Product Specifications
CAS Number
1877286-78-6
UNSPSC
12352005
Target
FLT3; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sg3-179.html
Smiles
O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C)C(NC4=CC=C(Cl)C(NS(=O)(C(C)(C)C)=O)=C4)=N3)C=C2F
Molecular Formula
C28H35ClFN7O3S
Molecular Weight
604.14
References & Citations
[1]Nerlakanti N, et al. Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018 Dec;17 (12) :2796-2810.|[2]Guan X. Discovery of Fluorescence Polarization Probes and Inhibitors for Testis-Specific Bromodomain and Extra-Terminal (BRDT) Proteins[J]. 2020.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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