ALKBH5 Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N (6) -methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Can also demethylate N (6) -methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105) . Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736) . Required for spermatogenesis (By similarity) .
Synonyms
ABH5; AlkB, alkylation repair homolog 5 (E. coli) ; AlkB, alkylation repair homolog 5; Alkylated DNA repair protein alkB homolog 5; Alpha ketoglutarate dependent dioxygenase alkB homolog 5; OFOXD; OFOXD1; Oxoglutarate and iron-dependent oxygenase domain containing; Probable alpha ketoglutarate dependent dioxygenase ABH5; RNA demethylase ALKBH5.
Gene ID
54890
Swiss Prot
Q6P6C2
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
1-100/394
Target
ALKBH5
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human ALKBH5
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
54890
Predicted Cross Reactivity
Human, Dog, Cow, Rabbit
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