Importin 8 Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.
Synonyms
FLJ26580; Imp 8; Imp8; Importin-8; Importin8; IPO 8; IPO8; IPO8_HUMAN; Ran binding protein 8; RAN BP8; Ran-binding protein 8; RANBP 8; RANBP8.
Gene ID
10526
Swiss Prot
O15397
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Rat
Immunogen
1-100/1037
Target
Importin 8
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic peptide derived from human Importin 8
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10526
Predicted Cross Reactivity
Human, Mouse, Cow, Sheep, Pig
Curated Selection
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