Phospho-SMAD7 (Ser249) Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonyms
SMAD7 (phospho S249) ; p-SMAD7 (phospho S249) ; Mothers against decapentaplegic homolog 7; FLJ16482; hSMAD 7; hSMAD7; MAD (mothers against decapentaplegic Drosophila) homolog 7; MAD; MAD mothers against decapentaplegic homolog 7; MADH 7; MADH7; MADH 8; MADH6; MADH8; Mothers Against Decapentaplegic Drosophila Homolog of 6; Mothers Against Decapentaplegic Drosophila Homolog of 7; Mothers against decapentaplegic homolog 7; Mothers against DPP homolog 7; SMAD 7; SMAD; SMAD family member 7; SMAD, mothers against DPP homolog 7 (Drosophila) ; SMAD, mothers against DPP homolog 7; SMAD6; Smad 6; Smad-6; SMAD7; SMAD 7; SMAD-7; SMAD7_HUMAN.
Gene ID
4092
Swiss Prot
O15105
Modification Site
Ser249
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-SMAD7 (Ser249)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE
Source
KLH conjugated synthetic peptide derived from human Phospho-SMAD7 (Ser249)
Applications
WB, IF
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF ()
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4092
Curated Selection
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