MCM3 Polyclonal Antibody, PerCP Conjugated
Product Specifications
Background
MCM3 is one of the highly conserved mini-chromosome maintenance proteins that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Synonyms
Minichromosome maintenance deficient 3; Cervical cancer proto oncogene 5; DNA polymerase alpha holoenzyme associated P1; DNA polymerase alpha holoenzyme associated protein P1; DNA replication factor MCM3; DNA replication licensing factor MCM3; HCC 5; HCC5; hRlf beta subunit; Human cervical cancer proto oncogene 5; MCM 3; MCM3 minichromosome maintenance deficient 3; MGC1157; Minichromosome maintenance deficient 3; Minichromosome maintenance protein 3; P1 h; P1 MCM3; P1 Protein; P1.h; P102 protein; Replication licensing factor beta subunit; RLF beta subunit; RLF subunit beta; RLFB.
Gene ID
4172
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
251-350/808
Target
MCM3
Clonality
Polyclonal
Isotype
IgG
Conjugation
PerCP
Source
KLH conjugated synthetic peptide derived from human MCM3
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
482nm/677nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4172
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit
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