ABI1 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Synonyms
E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1; Abl interactor 1; Abelson interactor 1; Abl-binding protein 4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Spectrin SH3 domain-binding protein 1; ABI1
Gene ID
10006
Swiss Prot
Q8IZP0
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Immunogen
101-200/508
Target
ABI1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human ABI1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10006
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Horse, Chicken, Rabbit
Curated Selection
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