SOCS2 Polyclonal Antibody
Product Specifications
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms
CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2; Suppressor of cytokine signaling 2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SOCS2
Gene ID
8835
Swiss Prot
O14508
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
1-100/198
Target
SOCS2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Socs 2
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
8835
Predicted Cross Reactivity
Mouse, Dog, Cow, Pig, Horse
Curated Selection
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