MCM-BP Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
Synonyms
C10orf119 ; chromosome 10 open reading frame 119 ; MCM-binding protein ; MCM-BP ; mcmbp ; MCMBP_HUMAN ; Mini-chromosome maintenance complex-binding protein ; Minichromosome maintenance complex binding protein.
Gene ID
79892
Swiss Prot
Q9BTE3
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Rat
Immunogen
551-642/642
Target
MCM-BP
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human MCM-BP
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
79892
Predicted Cross Reactivity
Human, Mouse, Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit
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