MAGI3 Polyclonal Antibody, Cy3 Conjugated
Product Specifications
Background
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Synonyms
DJ730K3.2; MAGI-3; magi3; MAGI3_HUMAN; Membrane Associated Guanylate kinase Related 3; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; RP4-730K3.1; SLIPR; WW and PDZ domain-containing protein 3
Gene ID
260425
Swiss Prot
Q5TCQ9
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
181-280/1506
Target
MAGI3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy3
Source
KLH conjugated synthetic peptide derived from human MAGI3
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
512,550nm/570,615nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
260425
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Sheep, Pig, Chicken, Rabbit
Curated Selection
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