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PPARGC1A Polyclonal Antibody, APC-Cy7 Conjugated

Product Specifications

Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene.

Synonyms

LEM6; PGC-1 Alpha; PGC1 Alpha; Ligand effect modulator 6; Peroxisome prolerative activated receptor, gamma, coactivator 1 alpha; Peroxisome prolerative activated receptor, gamma, coactivator 1 ; Peroxisome prolerator activated receptor gamma coactivator 1 alpha; PGC 1 alpha; PGC 1 alpha; PGC 1v; PGC1; PGC1alpha; PGC1A; PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPARGC 1 alpha; PPARGC1A.

Gene ID

10891

Swiss Prot

Q9UBK2

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human

Immunogen

601-700/798

Target

PPARGC1A

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC-Cy7

Source

KLH conjugated synthetic peptide derived from human PPARGC1A

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/780nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

76% homology with PGC1 beta

Gene ID URL

10891

Predicted Cross Reactivity

Mouse, Rat

Curated Selection

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