LNX1 Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Lnx1 is a membrane-bound protein that is involved in signal transduction and protein interactions. Lnx1 is an E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lnx1 mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
Synonyms
E3 ubiquitin protein ligase LNX; Ligand of Numb protein X 1; Ligand of numb protein X 1 E3 ubiquitin protein ligase; LNX; LNX1; LNX1_HUMAN; MPDZ; Multi PDZ domain containing protein E3 ubiquitin protein ligase LNX; Numb binding protein 1; PDZ domain-containing ring finger protein 2; PDZRN2.
Gene ID
84708
Swiss Prot
Q8TBB1
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
101-200/728
Target
LNX1
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic peptide derived from human LNX1
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
84708
Predicted Cross Reactivity
Human, Cow, Sheep, Horse
Curated Selection
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