CCR6 inhibitor 1
Product Specifications
UNSPSC Description
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1].
Target Antigen
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/CCR6_inhibitor_1.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S([C@H](CC1)CC[C@@H]1NC2=NC=C(C(F)(F)F)C=C2)(C3=CC=C(C4=CC=NC(C(N)=O)=C4)C=C3)=O
Molecular Weight
504.52
References & Citations
[1]Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112701/CCR6-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112701/CCR6-inhibitor-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2437547-04-9
Available Sizes
Curated Selection
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