CCR6 inhibitor 1

CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM) . CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1].

Product Specifications

CAS Number

[2437547-04-9]

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CCR6_inhibitor_1.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S([C@H](CC1)CC[C@@H]1NC2=NC=C(C(F)(F)F)C=C2)(C3=CC=C(C4=CC=NC(C(N)=O)=C4)C=C3)=O

Molecular Formula

C24H23F3N4O3S

Molecular Weight

504.52

References & Citations

[1]Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28 (18) :3067-3072.