Mettl14 Polyclonal Antibody

Product Specifications

Background

N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop (By similarity) . M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (PubMed:24394384) .

Synonyms

MKIAA1627; G430022H21Rik; N6-adenosine-methyltransferase subunit METTL14; Methyltransferase-like protein 14; Mettl14; Kiaa1627

Gene ID

210529

Swiss Prot

Q3UIK4

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Immunogen

21-120/456

Target

Mettl14

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic peptide derived from mouse Mettl14

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

210529

Predicted Cross Reactivity

Cow, Pig, Horse, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MF-0106634-01 5 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details

MF-0106634-02 10 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details

MF-0106634-03 20 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details

MF-0106634-04 50 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details

MF-0106634-05 100 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details

MF-0106634-06 200 µg

ZG16 Protein, Human, Recombinant (His)

Ask

View Details