DR5 Polyclonal Antibody, AbBy Fluor™ 488 Conjugated

Product Specifications

Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis (By similarity) .

Synonyms

MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; CD262; Tnfrsf10b

Gene ID

21933

Swiss Prot

Q9QZM4

Cellular Locus

Cell membrane

Host

Rabbit

Cross Reactivity

Human

Immunogen

301-381/381

Target

DR5

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 488

Source

KLH conjugated synthetic peptide derived from mouse DR5

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

499nm/519nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

21933

Predicted Cross Reactivity

Mouse, Rat

Available Sizes

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