(S) - (+) -Ibuprofen

(S) - (+) -Ibuprofen ((S) -Ibuprofen), a S (+) -enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S) - (+) -Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects[1][2].

Product Specifications

CAS Number

[51146-56-6]

Product Name Alternative

Dexibuprofen

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/_S_-__addition__-Ibuprofen.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming)

Smiles

OC([C@H](C1=CC=C(CC(C)C)C=C1)C)=O

Molecular Formula

C13H18O2

Molecular Weight

206.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Evans AM, et al. Comparative pharmacology of S (+) -ibuprofen and (RS) -ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.|[2]N Scheuren, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123 (4) :645-52.|[3]Astrid Janssen, et al. Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. Eur J Pharmacol. 2006 Jul 1;540 (1-3) :24-33.