Phospho-GRK2 (Ser670) Polyclonal Antibody, RBITC Conjugated
Product Specifications
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].
Synonyms
GRK2 (phospho S670) ; p-GRK2 (phospho S670) ; G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.
Gene ID
156
Swiss Prot
P25098
Modification Site
Ser670
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Phospho-GRK2 (Ser670)
Clonality
Polyclonal
Isotype
IgG
Conjugation
RBITC
Source
KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
570nm/595nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
156
Predicted Cross Reactivity
Rat, Dog, Cow, Pig, Horse, Rabbit
More Discoveries
Explore Other Products
Browse additional items from our catalog
M4700-06K-ML490 100 µL
Mucin 1 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Sequence, H23 Antigen, H23AG, HGNC:7508, MAM6, Mucin 1 Precursor, Mucin 1 Transmembrane, Peanut-reactive Urinary Mucin, PUM, Polymorphic Epithelial Mucin, PEM, PEMT, Tumor Associated Epithelial Membrane Antigen, Tumor Associated Mucin) (MaxLight 490)
Sign In for Pricing
View Details 
K1889408 1.0 µg DNA
RPL7P8 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
Sign In for Pricing
View Details E45M15157V-2 50 µL
PI 3 Kinase Class 2A (PIK3C2A) Mouse Monoclonal Antibody [Clone 1B5]
Sign In for Pricing
View Details MBS7034481-01 0.02 mg
Recombinant Escherichia coli Inner membrane protein yhaI (yhaI)
Sign In for Pricing
View Details