Phospho-GRK2 (Ser670) Polyclonal Antibody, APC Conjugated
Product Specifications
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].
Synonyms
GRK2 (phospho S670) ; p-GRK2 (phospho S670) ; G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.
Gene ID
156
Swiss Prot
P25098
Modification Site
Ser670
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Phospho-GRK2 (Ser670)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
156
Predicted Cross Reactivity
Rat, Dog, Cow, Pig, Horse, Rabbit
Curated Selection
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