BAY-179
BAY-179, a chemical probe, is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively[1].
Product Specifications
CAS Number
2764880-87-5
UNSPSC
12352005
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-179.html
Purity
99.83
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=C(OC(C3=CSC(C4CCN(CC5=NC6=C(C=CC=N6)N5)CC4)=N3)=C2)C=CC=C1
Molecular Formula
C23H21N5OS
Molecular Weight
415.51
References & Citations
[1]Mowat J, et al. Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179. ACS Med Chem Lett. 2022;13 (3) :348-357. Published 2022 Feb 18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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