GPR161 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Product Specifications
Background
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity) .
Synonyms
RE2; G-protein coupled receptor 161; G-protein coupled receptor RE2; GPR161
Gene ID
23432
Swiss Prot
Q8N6U8
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
121-220/529
Target
GPR161
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 680
Source
KLH conjugated synthetic peptide derived from human GPR161
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
679nm/702nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
23432
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Sheep, Pig, Horse
More Discoveries
Explore Other Products
Browse additional items from our catalog
130584-ML490 100 µL
NSF (Vesicle-fusing ATPase, N-ethylmaleimide-sensitive Fusion Protein, NEM-sensitive Fusion Protein, Vesicular-fusion Protein NSF) (MaxLight 490)
Sign In for Pricing
View Details 