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Stemregenin 1

Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.

Product Specifications

Product Name Alternative

SR1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/StemRegenin-1.html

Purity

99.95

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1

Molecular Formula

C24H23N5OS

Molecular Weight

429.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Boitano AE, et al.
 Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. 
 Science. 2010 Sep 10;329 (5997) :1345-8.|[2]Gao H, et al. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24;287 (35) :29979-87.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15001/Stemregenin-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15001/Stemregenin-1-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

CAS Number

[1227633-49-9]

Available Sizes

Curated Selection

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