Stemregenin 1

Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.

Product Specifications

CAS Number

[1227633-49-9]

Product Name Alternative

SR1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/StemRegenin-1.html

Purity

99.95

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1

Molecular Formula

C24H23N5OS

Molecular Weight

429.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Boitano AE, et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells.  Science. 2010 Sep 10;329 (5997) :1345-8.|[2]Gao H, et al. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24;287 (35) :29979-87.