Stemregenin 1
Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM.
Product Specifications
CAS Number
1227633-49-9
Product Name Alternative
SR1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/StemRegenin-1.html
Purity
99.95
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1
Molecular Formula
C24H23N5OS
Molecular Weight
429.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Boitano AE, et al.
 Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. 
 Science. 2010 Sep 10;329 (5997) :1345-8.|[2]Gao H, et al. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012 Aug 24;287 (35) :29979-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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