Talmapimod
Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC50 of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome) [1][2][3][4].
Product Specifications
CAS Number
309913-83-5
Product Name Alternative
SCIO-469
UNSPSC
12352005
Target
Apoptosis; Interleukin Related; p38 MAPK; TNF Receptor; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SCIO-469.html
Concentration
10mM
Purity
98.68
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O
Molecular Formula
C27H30ClFN4O3
Molecular Weight
513.00
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P38α; p38β
Available Sizes
Frequently Asked Questions
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